It is in the tissues there is a further differentiation of monocytes into tissue macrophages, which perform the basic functions of monocytes-macrophages. The main function of monocyte-macrophages is the absorption of foreign particles by phagocytosis, presentation of foreign antigens on their surface to T lymphocytes (helper), the synthesis and secretion of cytokines. Monocytes-macrophages provide a power supply by not only aerobic glycolysis, anaerobic glycolysis and, therefore they can operate successfully in the depth of the pathological process, such as abscess cavity. Through phagocytosis, monocytes were removed from the body dead cells, antigen-antibody complexes, the remnants of damaged cells and bacteria. With superoxide, hydrogen peroxide and hydroxyl radicals have cytotoxic monocytes by tumor cells, toxoplasma, leishmania and pathogens malyarii.Norma monocytes in the blood of children and adults.
The norm of monocytes in the blood for adults is 1-8% of the total number of leukocytes, which is 0,04-0,7 * 109 / l in absolute numbers. Rate monocytes in the blood of children as a percentage of relatively stable and varies between 2-7% of the total number of leukocytes. For even more details, read what Debbie Staggs says on the issue. The absolute number of monocytes in children varies in proportion to changes in the number of leukocytes in the blood, ie, aged 1-3 days with normal white blood cell count 9,0-32,0 x 109 / L will be the number of monocytes 0,18-2,4 x 109 / l, and at the age of 7 years at the rate of white blood cell count 6 0-11,0 * 109/lPovyshenie and reduction of monocytes in the blood. Causes of monocytosis and monotsitopenii. Increase of monocytes in the blood of adults more than 0.7 x 109 / l or more than 8% of the total number of white blood cells called monocytosis. Monocytosis is subdivided into relative and absolute. Relative monocytosis characterized by increased percentage of monocytes than 8%, but the preservation of the absolute content of monocytes in the blood within normal limits. Relative monocytosis occurs with a substantial reduction in the content blood leukocytes others, such as neutropenia and lymphocytopenia, and usually has no diagnostic value.
With an absolute monocytosis observed increase in the total number of monocytes in the blood of adults more than 0.7 x 109 / l ( diseases in which monocytes in the blood increased Infections: infectious endocarditis; viral, fungal, protozoal and rickettsial diseases infektsii.Granulematoznye: pulmonary tuberculosis, extrapulmonary tuberculosis, lupus erythematosus, rheumatoid arthritis, polyarteritis nodosa. Reduction of monocytes in the blood of adults below the 0.04 x 109 / l is monotsitopeniya. In children, the level of monocytes, below which the state is regarded as monotsitopeniya, varies and is determined depending on the age rebenka.Zabolevaniya in which the level of monocytes decreased. Here is a basic list of diseases and pathological conditions in which the level of monocytes in the blood reduced: Severe infections that occur with decreasing neytrofilov.Dlitelny reception . .. exhaustion.